PostDoc or PhD Position- Analysis of Cell Free DNA in Aggressive B Cell Lymphomas

At the University Hospital of Giessen and Marburg, Institute of Pathology, Gießen we are seeking a PostDoc or PhD for the Department of Molecular Cytology and Functional Genomics

The position is initially limited to 3 years, part-time (75%).

Research Environment

Molecular Cytology and Functional Genomics

The Department of Molecular Cytology and Functional Genomics employs a multi­di­sci­plinary approach combining genetic, cell biolo­gical, and bioche­mical inves­ti­ga­tions to identify and functionally charac­terize the trans­forming events involved in the patho­ge­nesis of B‑cell lymphomas. The results of these studies lead to improved diagnosis of these diseases and are used to develop prognostic markers for therapy. In addition, new thera­peutic strategies are designed and validated in precli­nical studies.

Research Project — Liquid Biopsies of Aggressive B‑cell Lymphoma

After deter­mining the genetic lesions of a B‑cell lymphoma at the time of diagnosis, high-throughput sequencing is subse­quently performed using blood samples from these patients, both during and after therapy. The so-called liquid biopsy procedure usually allows for the detection of tumor DNA in the blood of patients at the beginning of therapy. Studies with these methods in NHL patients show that there is a corre­lation between the response to therapy and the detec­ta­bility of tumor DNA in the blood. Accor­dingly, the detection of tumor DNA in the blood allows the course of therapy to be monitored closely. After completion of therapy, the ultra­sen­sitive detection of circu­lating tumor DNA allows early predic­tions of possible relapses or trans­for­ma­tions of the B‑cell lymphoma.

Your profile

• Master or PhD degree in bioinformatics/computational biology, genomics or a related area
• Extensive experience with at least one programming language (e.g., R, Python, etc.).
• You have an interest in inter­di­sci­plinary colla­bo­ration.
• Dedication, team spirit, and a high degree of respon­si­bility.
• Very good English skills, both written and spoken.

We Offer

• A scien­tific project in the field of trans­la­tional cancer research.
• Excellent, inter­di­sci­plinary super­vision by a Principal Inves­ti­gator and Postdocs, as well as support for the sustainable develo­pment of your scien­tific profile.
• Oppor­tunity to pursue a doctorate (PhD).
• Oppor­tunity to analyze a broad spectrum of high-throughput sequencing data (including analysis of circu­lating tumor DNA using PhasED-Seq, exome sequencing, RNA-seq, etc.).
• Focus institute “Liquid Biopsy” within the framework of the “CCC Hessen” initiative.
• Innovative concepts in digital higher education.
• Support for external conti­nuing education and training.

How to apply:

Please send your appli­cation documents to roland.schmitz@patho.med.uni-giessen.de until October 20th, 2024, including:

 a CV with publi­cation list (if available)

a summary of previous research experience (max 1 page)

copies of certi­fi­cates, transcripts and grades

For more infor­mation about the lab and project, please contact Prof. Dr. rer. nat. Roland Schmitz roland.schmitz@patho.med.uni-giessen.de.