The Institute for Computational Genomics, RWTH Aachen University
performs cutting edge research on computational and genomic methods
for understanding regulatory and epigenetic processes driving cell
differentiation and diseases. In this project, we are particularly
interested in studying RNA-DNA interactions as mechanisms of
transcriptional control. For example, we have recently shown how the
long-noncoding RNA HOTAIR interacts with DNA via triple helices to
control the expression of stem cell differentiation (Kalwa et al.,
We are looking for a postdoc candidate to work on sequence analysis
algorithms for detection of RNA-DNA triple helices and for analysis of
novel target sequencing protocols, which capture triple helix forming
RNA and DNA molecules. This project will be performed in collaboration
with cell biologists of the Medical Faculty, RWTH and of the German
Centre of Cancer Research (DKFZ), Heidelberg.
Applicants should hold a Ph.D. in Bioinformatics or Computer Science.
Experience in the analysis of biological sequences and regulatory
genomics is required. The candidate should have solid programming
skills (C, Python and/or R) and acquaintance with Unix/Linux.
Experience with high performance computing is a plus. The working
language of the group is English. The position is a full time position
to be filled as soon as possible. The candidate will have the
possibility to perform his habilitation. The salary corresponds to
level 13 TV-L. Interested candidates should send a brief statement, of
research interests, CV and the names of three references to
RWTH Aachen is one of the members of the German Excellence Initiative
and one of the leading technical universities in Europe. It is located
at the Euroregio tri-border region neighboring Netherlands and
Belgium, which provides unique life and work opportunities. We
particularly welcome and encourage applications from women, disabled
people and ethnic minority groups, recognizing they are
underrepresented across RWTH Aachen University. The principles of fair
and open competition apply and appointments will be made on merit.