- Veröffentlicht: Freitag, 23. Juni 2017 11:51
The Boztug Lab at CeMM in Vienna is searching for a motivated postdoctoral fellow for a project within a productive scientific collaboration with the Menche Lab at CeMM. We joined forces to realize an ambitious project at the intersection of rare disease genetics, network biology and precision medicine that has the potential to have a lasting impact on each of these three fields.
The Project — There are more than 7,000 rare diseases and collectively they affect around 5% of the population. Many of them are caused by single-gene defects and thereby offer unique opportunities to establish clear mechanistic genotype-phenotype relationships. To establish the precise molecular mechanisms by which individual gene aberrations perturb cellular networks, systems biology approaches will be instrumental. Rare diseases thus have extraordinary potential to serve as a paradigm for precision medicine that bridges the gap between wholistic, systems based analyses and actionable insights for personalized therapy. The overarching goal of the joint project is to rationalize patient-specific workflows from gene discovery and underlying pathomechanisms to targeted therapy. The project lead by Kaan Boztug will focus on using network biology to more efficiently identify novel disease etiologies underlying immunodeficiencies and to systematically dissect rare disease clusters to compare to more common immune disorders and to predict drug responses. The project will also involve the development of multi-layer network approaches to integrate diverse genomic data into a predictive platform for personalized medicine. This research project is funded by WWTF (https://www.wwtf.at).
The Research Groups — Kaan Boztug (www.rare-diseases.at) is a leading immunologist and rare diseases researcher and director of the newly founded Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD). His lab is interested in the genetics of rare primary immunodeficiencies and rare diseases of hematopoiesis with a special focus on disorders with autoimmunity and/or autoinflammation (Dobbs et al., NEJM 2015; Salzer et al., Nat Immunol 2016). His goal is to identify targets for tailored molecular therapies and to develop precision medicine approaches for diagnostics and treatment. His group applies a combination of state-of-the-art genomic technologies including next generation sequencing, a wide range of cellular and molecular techniques and innovative systems biology to elucidate novel pathways important for hematopoiesis and immune system homeostasis, to make a real impact by translating concepts and tools to the clinic. Jörg Menche (http://www.tinyurl.com/joergmenche) leads a newly established computational network medicine group and is an expert in analyzing large datasets derived from post-genomic technologies through the lens of network science (Menche et al., Science 2015).
The Institute (www.cemm.at) — CeMM is a flagship institute for biomedical research in the heart of Europe, Vienna. We are committed to highest scientific standards as exemplified by recent publications in top journals including Nature, Science and Cell. CeMM offers a uniquely dynamic, interactive and international environment and is located in a beautiful building at the center of the Medical University campus, within walking distance of Vienna’s historical city center. CeMM has been ranked among the top-5 best places to work in academia (http://the-scientist.com/2012/08/01/best-places-to-work-academia-2012).
Vienna is frequently ranked the world’s best city to live in. It is a United Nations city with a large English-speaking community. The official language at CeMM is English, and more than 40 different nationalities are represented at the institute.
We are convinced that diversity and a multicultural work environment are clear advantages for successful research and are committed to attract, develop, and advance the most talented individuals regardless of their gender, race, sexual orientation, religion, age, disability status or any other dimension of diversity.
Why you want to join our team:
· You want to pursue meaningful research projects at the highest level in an inspiring and international working environment.
· You want to be part of the next generation of scientists that shape the future of medicine and value our numerous possibilities for personal and professional growth.
· You appreciate our young and dynamic working atmosphere and the possibility to join our cultural, social and sports activities.
· We are happy to provide help and assistance to all our employees, their spouses and family members in terms of visa and relocation procedures, dual-career and childcare services, and others.
· You wish to receive a competitive salary: your position will be remunerated according to FWF personnel costs (https://www.fwf.ac.at/en/research-funding/personnel-costs/) depending on qualifications and experience.
Why we want you to join our team:
· You are a proactive and independent thinker with a background in Bioinformatics, Systems or Network Biology, Complex Systems, or similar.
· You are enthusiastic and passionate about science.
· You are motivated to find innovative, creative and free-spirited solutions to open research questions.
· You love to communicate, to collaborate, to connect different scientific disciplines and to contribute to multidisciplinary and multicultural teams.
Application Details — Please apply online (https://cemm.jobbase.io/job/tarvvgt9) with a cover letter describing your career goals and explaining why you are the ideal candidate for this position, your detailed curriculum vitae and contact details of 2-3 referees. Please upload your full application here:
Ideally, you should please submit one Pdf file containing all of your application documents. Initial application deadline is 4th of August 2017 but the call will remain open until the position is filled. Candidates will be contacted by us on a rolling basis.